Nootropics and glutamic acid

Glutamic acid

Glutamic acid is an amino acid used by almost all living species, it contributes as an
 important part of biosynthesis for proteins, the human body makes it for its needs,
 it involves in the functions of the nervous system, the very interesting part is that
 it occurs in protein gluten which also happens to be the major protein of wheat,
 so it's plenty around us,(1)

It is manufactured by either hydrolysis of the protein gluten, or from wastewater
 of beetroots, or by fermentation

What is the connection of glutamic acid with the brain?

This is an amino acid that is involved between nerve cells and brain cells, which means
 it involved in sending and receiving information, so its very key amino acids involved
 with brain functions,(2)

let's see
nootropics-facts,glutamic-acid
                               nootropics and glutamic acid

Does MSG, monosodium glutamate has the same acid?


Yes, its the same acid, only here it is used as the sodium salt, MSG has a lot of controversy
and some people working with the health system regard this as a little unsafe, although
the FDA says it's very safe. Its food additive also called as number E621 used very widely
as a flavor enhancer in processed foods
MSG contributes in a very big way as a flavor enhancer mainly for savory, meaty, and
 umami foods, here umami is referred to as the fifth taste along the line of salty, sour,
 bitter, and sweet today daily intake of MSG in the US and UK is about 0.55-to-0.58
 gram per day, while the same in Japan and Korea is about 1.2-to-1.7 gram per day

Why MSG regarded by some people as a little unsafe?

There is not much research support for this, of course, very large doses of MGS can raise
glutamic acid levels in the blood, which means increased glutamate activity in the brain and 
can harm, but who eats that kind of high amounts

Glutamic acid health benifites

Although not much research has been done, whatever very little information we have it is
helpful in a number of health conditions

-may be helpful in treating childhood behavioral issues
-maybe helpful in personality development, mainly to Childs
-may be helpful for the treatment of epilepsy and muscular dystrophy
-maybe helpful in managing intellectual disorders
-may be helpful in the treatment of low blood sugar,(hypoglycemia) in diabetics
-maybe in preventing nerve damage in cases of chemotherapy

Glutamic acid side effects, toxicity, and possible interactions

In practice glutamic acid is not taken as a signal item most of the time it is used
in formulations along with either other amino acids or with vitamins, and again
in the formulations pinpointing side effects is a little difficult, but again what

research says,(3)

no high dose for a long lime
no for women, pregnant or breastfeeding
no for someone who has maple syrup urine disease, or MSUD, a kind of metabolic disorder
no for cystinuria, its a kidney disorder

Why glutamic acid is important as nootropics?

There is very little research information we have about its direct role as nootropics
but as it is a very important part of the glutamine cycle which really involved in high
levels of nootropics activity, it might be thought that this acid may also be useful
in nootropics activity.

let's see
nootropics-facts,glutamic-acid
                           nootropics and glutamic acid


Is glutamic acid is used as a nootropic in formulations?

Yes, and that is the reason we are trying to cover its all facts so that it should be more 
clear, whether it should be used or not, as for as commercial information is concerned
glutamic acid is a part of formulations that are marketed as supplements meant for
nootropics

So, what is a recommendation from Nootropics Facts, as already you see it does have
indirect relation with glutamine, but whether glutamic acid also works in a very good way
is not very clear, there is not much research support on this




How to buy nootropics

How to buy nootropics? 

Most of the nootropics which are natural type and some drug type you can purchase from any pharmacy on the counter or you can buy from online suppliers. before buying the most important  is to make sure that you are buying the correct stuff for this,(1)

Let's see 

nootropics-facts,how-to-buy
                                      How to buy Nootropics

Read the labels very thoroughly

Read the reviews  about products 

If possible  discuss with your doctor 

Use the product very strictly  according to  instructions 

You can also buy supplements,  they have formulated mixtures of more than one nootropic and some of them are very successful, you can again buy them from online suppliers, like Amazon




Nootropics and Choline

What is choline?

Very recently only in 1998, choline is recognized as an essential nutrient,  and this is made by the body for its own needs.it's required for the normal function of the body for normal health. Although the body makes but a large amount also comes from food that we take every day.It's an organic, water-soluble  compound its neither vitamin nor mineral  and often grouped along with the vitamin B complex group due to its similarities,

 it impacts on

Liver function 

Healthy brain  function 

Nerves system  function 

Metabolism  function 

Therefore adequate  amounts  are always  needed for the body to function  properly,(1),(2) 

Let's see

nootropics-facts,choline

                                       Nootropics and choline

What choline does?

Choline plays a very important  role in many processes  going on in the body some of them are

Cell structure 

It makes the cell membrane 

Cell messaging 

It is involved in  the  production  of  compounds  that acts as cell messengers at transport and metabolism It's required  for removing the cholesterol  from the liver, if it is inadequate  then there is the buildup of cholesterol  levels 

DNA synthesis 

Choline with vitamin -B12, and Folic acid takes part and produce DNA

Nervous system  maintenance 

It's important to produce  acetylcholine which is a neurotransmitter for the nervous system 

And this is also involved  in 

Memory 

Muscle movement 

Heartbeat regulations 

Other basic functions 

How much is required? 

This also depends on  gender and age and health conditions but a healthy individual  needs about 550mg/ day

What are health benefits? 

1., May be helpful to  Heart health 

Choline may reduce the risk of heart  disease  by lowering the homocysteine levels 

2,:-May help in Brain problems 

It regulates and improves 

Memory, mood, and intelligence 

Better memory and processing

Brain development 

Mental health  disorders 

Mood disorders 

Bipolar disorder 

3,:-May help in liver disease 

It reduces  liver risk by 28%

4,:-May help in Cancer

There are mixed results  and more research is  needed

What are the negative impacts? 

Taking too much choline  can be harmful it can create  side effects  such as a drop in blood pressure, sweating, fishy body odor, diarrhea, nausea, and vomiting The upper limit is 3500mg/day, this limit is just not possible if you are not taking any choline supplements,(3),(4)

Does it good for nootropics? 

It has all properties to help Brain, and because of that it is good for nootropics and in fact is already present in many supplements meant for nootropics. 

So, where does choline stands, as for as nootropics facts are concerned choline is too important as a nootropic, about nootropics activity its basic molecule involve in brain activities, we think choline and choline derivatives can be a very interesting choice as nootropics?






Nootropics and Carnitine

What is Carnitine?

L-Carnitine is a derivative of naturally occurring amino acid, its very popular,  and used for bodybuilding, fitness, and weight loss programs as a supplement. In a broad sense, it is a nutrient and dietary supplement 

It's produced in labs and it is a synthetic product, the body itself produces it for its needs, very small amounts it can be managed from food, what we eat particularly meat and fish. For some people, vegans or people with certain  genetic  issues, it has to be given as a supplement,(1).,(2)

 Let's see 

nootropics-facts,carnitine
                            Nootropics and  Carnitine

What are different types of carnitine?

The several types of carnitine which are used for supplements  are

L- Carnitine

This is the most required type and standard  bioactive form of carnitine

D-Carnitine

This is a very inactive form, it should not be used

Acetyl- Carnitine

Most active form for the brain, this is more beneficial for people with neurodegeneration.

Propionyl - L-Carnitine

More active form for blood circulation improves blood flow

L -Carnitine-L-Tartarate

More active form for supplements  meant for sports, weight loss For most people, acetyl-L-Carnitine is the best working type

How it works? 

Its main role in our body is

1,:-Energy production

2,:-Mitochondrial function

In cells carnitine transport fatty acids, where they burn and produce energy,  for this purpose, most carnitine, about 90% only contained in muscles where it produces energy by utilizing fatty acids as fuel, and in turn, it helps in weight loss.

Where it occurs in nature?

nootropics-facts,carnitine
                            Carnitine  in Nature


What are the health benefits of  Carnitine? 

Carnitine is associated with energy production that too in muscles, where it utilizes fatty acids rather than carbohydrates.

1,:-May help in weight loss

It really works, research studies confirm this.

2,:-May help in exercise  performance 

These benefits  are indirect and it takes  time, these are long term benefits,(3) 

Recovery

May improve  exercise  recovery 

Muscle oxygen supply

May increase oxygen supply to muscles

Stamina 

May increase blood flow,  delay discomfort, and reduce fatigue 

Muscle Soreness

May reduce muscle  soreness after exercise 

Red blood cell  production 

May increase the production of red blood  cells, which are also responsible  for oxygen 

Transport to full body

3,:-May help brain

It provides  almost all-round  health benefits  in this area studies suggested that

It prevents age-related mental decline

It improves  markers of learning 

It protects the brain from cell damage 

4:-May help Heart

It reduces  blood pressure 

It increases blood  circulation 

5,:- May help in diabetes  type2

It reduces blood sugar levels 

It improves  your body ability  to use carbohydrates 

What are the negative impacts? 

There are no negative effects  seen  in people  taking it 3 gram/ day, some people  reported  some mild side effects  such as  nausea and  stomach discomfort 

What should be dosed?

Although  recommend doses varies from 500 to 2000 gram/day depending on for what the purpose it is  used

Who should take it?

Older adults,  vegans, and vegetarians

Some very specific  use such as for cases of brain, and blood circulation 

Does it good for nootropics? 

If you see it used for more betterment for the brain, so it should  be used as nootropics in fact, it is used in a lot of supplements  meant for nootropics 

So what we have to say about this, from nootropics facts point of view, it's most trusted drug today, about nootropics activity, it has more than enough activity in the area of brain and brain functions, its side effects are also very limited, all said and done it can be very good choice.