Nootropics and alpha-GPC

What is Alpha-GPC?

Its total exact name is L-alpha glycerylphosphorylcholine or another most used name

cholinealfoscerate,a natural choline compound, occurs in the brain, and its role is to transfer

choline across the blood-brain barrier

It also happens to be a biosynthetic precursor for acetylcholine, in lay-man terms it 

converts itself to acetylcholine,in the bioprocess which is constantly going on in

the body, more particularly in the brain.

Today its made in a lab and can be used as medicine,(1)

What is the role of Alpha-GPC?

As discussed its role is to manage, regulate choline in the brain, because of its this role

it becomes very important as nootropics, by taking it as a supplement, provides more

acetyl-choline, and intern more benefits to brain problems,(2)

,

Production of Alpha-GPC

Mostly it is made by a chemical or enzymatic process from soya phospholipids, which also

occurs in lecithin, mostly from eggs and soya

Sources of Alpha-GPC

Its look like its widespread in most of food products but only in very small amounts, 

the sources maximum rich are only just follow

Wheat bread.....................................     4,93 mg/100 gram

Oat barn.............                                   33.25mg/100 gram

Cream cheese...........                             9.26 mg/100 gram

Yogurt..........               ..............          8-to-9-mg/100 gram

Bananas.........    .............                       5,60 mg/100 gram

Mushrooms..............         .............       5.11 mg/100 gram

Cabbage...........     ........            ........    3.47 mg/100 gram

Salmon..........     .............                      5.89 mg/100 gram

Comparison with other choline analogs

What reported is that Alpha-GPC works much better in compression with

other choline analogs means it needs only 46% dose to create the same effect

what 100% dose of CDP-choline provides, so definitely it is more better

the choice for choline related treatments

Alpha-GPC affects on Obesity and Fat- and Weight-reduction

As we already discussed, not much research data is available, but whatever we have

indicates that it works, it creates LIPOLYSIS, which means creates ketones and free fatty

acids, once it is taken in, a similar condition which is created by keto-diet.

lets see

                                  nootropics and alpha-GPC

It can affect physical performance

It is reported to increase about 14% more out-put, if it is taken about 45- minutes before

exercise

It improves the conditions of Ischemia and Stroke cases

Very significant improvements are reported in these cases, it's very important neuroprotective

in both cases

What are the other health benefits of Alpha-GPC?

There is not much research inputs about its benefits, whatever very primary research data

available indicates that it can provide some good benefits in the following areas,(3),(4)

Alzheimer disease

It is reported to work in this case, improve the symptoms in a very considerable way

Dementia

It improves the conditions, behavior, mood, and thinking areas

Improve memory

Improve thinking  process

Improve learning

What are the side effects or negative effects of alpha-GPC?

Although it's very much tolerated, still some side effects are reported and most of

them are very mild in nature, they are heartburn, headache, dizziness, and in prolonged

use skin rashes

There is not much research information available so be on the very safe side and don't use

if you are pregnant or breast-feeding

What is the status and doses of this Alpha-GPC?

Most of the time it is available on the counter, which means you don't need prescription

about doses not much clear although its also depends on a lot of other conditions may be age

and health, follow the instructions provided by the supplier, mostly safe dose is 1000mg per day

in divided doses of 500mg.

Does Alpha-CPC is a very good nootropic?

Alpha-GPC is only working, in the area of the brain, as it is controlled and regulate the choline

it can be the safest choice for nootropics, and in fact, it is already used in a large scale for

this purpose only, and also the truth is it is used in a number of supplements meant for

nootropics.

Where does it stand from a nootropics-fact point of view?

When we see a lot of drugs for nootropics, this alpha-GPC just stands out as something very

special, at least it is safest and very active for brain functions, we think it can be and should

be considered as most important choice as nootropics

Nootropics and glutamic acid

Glutamic acid

Glutamic acid is an amino acid used by almost all living species, it contributes as an

 important part of biosynthesis for proteins, the human body makes it for its needs,

 it involves in the functions of the nervous system, the very interesting part is that

 it occurs in protein gluten which also happens to be the major protein of wheat,

 so it's plenty around us,(1)

It is manufactured by either hydrolysis of the protein gluten, or from wastewater

 of beetroots, or by fermentation

What is the connection of glutamic acid with the brain?

This is an amino acid that is involved between nerve cells and brain cells, which means

 it involved in sending and receiving information, so its very key amino acids involved

 with brain functions,(2)

let's see

                               nootropics and glutamic acid

Does MSG, monosodium glutamate has the same acid?

Yes, its the same acid, only here it is used as the sodium salt, MSG has a lot of controversy

and some people working with the health system regard this as a little unsafe, although

the FDA says it's very safe. Its food additive also called as number E621 used very widely

as a flavor enhancer in processed foods

MSG contributes in a very big way as a flavor enhancer mainly for savory, meaty, and

 umami foods, here umami is referred to as the fifth taste along the line of salty, sour,

 bitter, and sweet today daily intake of MSG in the US and UK is about 0.55-to-0.58

 gram per day, while the same in Japan and Korea is about 1.2-to-1.7 gram per day

Why MSG regarded by some people as a little unsafe?

There is not much research support for this, of course, very large doses of MGS can raise

glutamic acid levels in the blood, which means increased glutamate activity in the brain and 

can harm, but who eats that kind of high amounts

Glutamic acid health benifites

Although not much research has been done, whatever very little information we have it is

helpful in a number of health conditions

-may be helpful in treating childhood behavioral issues

-maybe helpful in personality development, mainly to Childs

-may be helpful for the treatment of epilepsy and muscular dystrophy

-maybe helpful in managing intellectual disorders

-may be helpful in the treatment of low blood sugar,(hypoglycemia) in diabetics

-maybe in preventing nerve damage in cases of chemotherapy

Glutamic acid side effects, toxicity, and possible interactions

In practice glutamic acid is not taken as a signal item most of the time it is used

in formulations along with either other amino acids or with vitamins, and again

in the formulations pinpointing side effects is a little difficult, but again what

research says,(3)

no high dose for a long lime

no for women, pregnant or breastfeeding

no for someone who has maple syrup urine disease, or MSUD, a kind of metabolic disorder

no for cystinuria, its a kidney disorder

Why glutamic acid is important as nootropics?

There is very little research information we have about its direct role as nootropics

but as it is a very important part of the glutamine cycle which really involved in high

levels of nootropics activity, it might be thought that this acid may also be useful

in nootropics activity.

let's see

                           nootropics and glutamic acid

Is glutamic acid is used as a nootropic in formulations?

Yes, and that is the reason we are trying to cover its all facts so that it should be more 

clear, whether it should be used or not, as for as commercial information is concerned

glutamic acid is a part of formulations that are marketed as supplements meant for

nootropics

So, what is a recommendation from Nootropics Facts, as already you see it does have

indirect relation with glutamine, but whether glutamic acid also works in a very good way

is not very clear, there is not much research support on this

How to buy nootropics? 

Most of the nootropics which are natural type and some drug type you can purchase from any pharmacy on the counter or you can buy from online suppliers. before buying the most important  is to make sure that you are buying the correct stuff for this,(1)

Let's see 

                                      How to buy Nootropics

Read the labels very thoroughly

Read the reviews  about products 

If possible  discuss with your doctor 

Use the product very strictly  according to  instructions 

You can also buy supplements,  they have formulated mixtures of more than one nootropic and some of them are very successful, you can again buy them from online suppliers, like Amazon

Nootropics and Choline

What is choline?

Very recently only in 1998, choline is recognized as an essential nutrient,  and this is made by the body for its own needs.it's required for the normal function of the body for normal health. Although the body makes but a large amount also comes from food that we take every day.It's an organic, water-soluble  compound its neither vitamin nor mineral  and often grouped along with the vitamin B complex group due to its similarities,

 it impacts on

Liver function 

Healthy brain  function 

Nerves system  function 

Metabolism  function 

Therefore adequate  amounts  are always  needed for the body to function  properly,(1),(2) 

Let's see

                                       Nootropics and choline

What choline does?

Choline plays a very important  role in many processes  going on in the body some of them are

Cell structure 

It makes the cell membrane 

Cell messaging 

It is involved in  the  production  of  compounds  that acts as cell messengers at transport and metabolism It's required  for removing the cholesterol  from the liver, if it is inadequate  then there is the buildup of cholesterol  levels 

DNA synthesis 

Choline with vitamin -B12, and Folic acid takes part and produce DNA

Nervous system  maintenance 

It's important to produce  acetylcholine which is a neurotransmitter for the nervous system 

And this is also involved  in 

Memory 

Muscle movement 

Heartbeat regulations 

Other basic functions 

How much is required? 

This also depends on  gender and age and health conditions but a healthy individual  needs about 550mg/ day

What are health benefits? 

1., May be helpful to  Heart health 

Choline may reduce the risk of heart  disease  by lowering the homocysteine levels 

2,:-May help in Brain problems 

It regulates and improves 

Memory, mood, and intelligence 

Better memory and processing

Brain development 

Mental health  disorders 

Mood disorders 

Bipolar disorder 

3,:-May help in liver disease 

It reduces  liver risk by 28%

4,:-May help in Cancer

There are mixed results  and more research is  needed

What are the negative impacts? 

Taking too much choline  can be harmful it can create  side effects  such as a drop in blood pressure, sweating, fishy body odor, diarrhea, nausea, and vomiting The upper limit is 3500mg/day, this limit is just not possible if you are not taking any choline supplements,(3),(4)

Does it good for nootropics? 

It has all properties to help Brain, and because of that it is good for nootropics and in fact is already present in many supplements meant for nootropics. 

So, where does choline stands, as for as nootropics facts are concerned choline is too important as a nootropic, about nootropics activity its basic molecule involve in brain activities, we think choline and choline derivatives can be a very interesting choice as nootropics?