L-Theanine

 How about nootropics L-Theanine?

L-Theanine mainly occurs in the tea plant, along with caffeine, and the nootropic

benefits of tea leaves are mainly due to this L-Theanine, it occurs in all types of

teas, black, brown. white, green, but more it occurs in matcha

It can be made synthetically in the lab but most preferred is naturally extracted

from tea leaves. On average it's present in about 1% in the dry weight of 

tea leaves,(1)

Apart from tea leaves it also reported occurring in some varieties of mushrooms

but in very low amounts

let's see

                     nootropics, l-theanine

What is L-Theanine?

Its amino acids, mainly present in tea, and overall it affects relaxation, focus

calming, and sleep, which all are required for some nootropics. It also has a

a very unique property that it can change taste perception to a great degree, 

which means it reduces the bitterness of chocolates and grapefruit if taken

along with this. It's another great activity is that it increases the sensation of

fullness means it increases the time between two food intakes, in layman terms

it reduces hunger,(2)

let's see

                    nootropics,l-theanine

How really L-Theanine works?

Mainly it effect the brain , and some very significant developments takes place 

moment you take L-Theanine or you take tea,(3)

-it increases the levels of GABA,serotonin,dopamine, all these works as

 neurotransmitters and contributes to the regulation of

--------emotions,mood,concentration,alertness, and sleep

--------appetite, energy,other cognitive skills

-it reduces the levels of excitatory brain chemicals, it means it reduces

 those chemicals which are responsible for stress and anxiety, and by

 doing so it reduces

--------stress, anxiety

-it enhances alpha-brain waves, its also called wakeful relaxation or

 in layman terms relax without sedating effect

------- improves sleep

Overall health benefits of L-Theanine?

As you have seen in the above para it mainly works with brain, it correct and

recorrect the brain functions, so in very obvious way its best in this area and

it really does wonders,(4)

-improves the brain functions, emotions,mood,concentrations,alertness,sleep

-reduces stress and anxiety

-reduce and maintain a healthy weight

What are the doses?

-for sleep,stress,anxiety 100-mg to-400-mg

-for other user a combination with caffeine where

--------caffeine 12-to-100-mg

--------theanine 30-to-100-mg

What are the side effects of L-Theanine?

It's very well tolerated in most the cases

-pregnant and breastfeeding, don't take without informing to doctor

-low blood pressure, as it can reduce more blood pressure, so carefully

-children, only after informing to doctor

What can be interactions?

If you are on some kind of medication then better discuss with your doctor

before taking it as it may have interaction with medicines of blood pressure

stress, anxiety, sleeping pill, etc

Also careful if you are taking stimulants, and any caffeinated drinks, or energy

drinks

Does L-Theanine work as a very good nootropic?

As you see it has most of the activity in the area of the brain, and in fact, it is already

very well used in a lot number of supplements meant for nootropics, so there should

not be any doubt about its working as a great nootropics

So, where do we stand in this case of L-Theanine, from this blog,

 About Nootropics, Nootropics Facts?

As we are in the process of analyzing a number of ingredients natural and or

synthetic which have nootropic activity, this L-Theanine is one of the most 

promising one and because of its greater benefits it's used in a large number

of commercial preparations meant for nootropics, so you can try to use this

as a supplement which is available today in tablet form, we very strongly

recommend it to aged persons and also persons who are in the sports activity

MIND Diet

 What is the MIND Diet?

As the name suggests, it is the diet for the mind, and of course, its a highly dedicated diet

for the protection and health of the brain, you can say it is for controlling the decline of

brain health due to aging, It is developed by nutritional epidemiologist Martha Clare Moris

at Rush University Medical center and data is published in 2015

Its combination of two top diets Mediterranean and DASH, and in this combination all 

those foods are removed which can affect the brain,(1),(2)

MIND Diet can lower the Alzheimers risk to about 35% who follow this diet and

also reported to lower the risk about 53% who adhere to it rigorously

let's see

                     nootropics facts, MIND Diet

The Rush research team has done follow up research studies and they concluded that it

maybe a better diet than both DASH and Mediterranean diets prevents cognitive decline

in a very significant way,(3)

One more study, that two done very recently in 2020, concluded that

MIND Diet can

-it prevents dementia

-it reduces the harmful effects due to obesity

-it increases cognitive ability

-it protects the brain structure

-it can reduce the weight, that too quick weight loss

-it boosts brainpower

-it decreases oxidative stress and inflammation

-it reduces potentially harmful beta-amyloid proteins

let's see

                    nootropics facts, the MIND diet

What exactly is this diet?

It is around, leafy greens, nuts, and berries and planed in such a way that carbohydrates

should be present in minimum possible amounts,(4),(5)

            

What are the foods to be avoided?

-whole dairy products

    butter and margarine, less than 1-tbsp per day

    cheese, once a week only

-Red meat, not more than 3-serving per week

-pastries

-sweets

-fried foods

-Very strictly avoid  saturated and trans fats

What foods we must eat in this diet?

It recommends these foods to be taken very regularly

-Green, leafy, vegetables,

  6-serving per week, includes, kale,spinach, cooked green, and salad

-Other vegetables

 Once in a day, nonstarchy vegetables

-Berries

  twice a week, strawberries, blueberries, raspberries, and blackberries

-Nuts

  5-serving per week, vary the type and varieties

-Olive oil

 this is the oil recommended by the mind team

-Whole grains

  3-serving daily, oatmeal, quinoa, brown rice, whole-wheat pasta, whole wheat bread

-Beans

  4-times a week, all beans, lentils, soybeans

-Poultry

 2-times a week, chicken, or turkey, but not fried

-Fish

 once a week,salmon,sardines,trout,tuna,mackerel

-Wine

  not more than one glass daily, more preferred red-wine

let's see

                    nootropics-facts, MIND Diet, what is allowed

How the diet works?

In one week of the program what you should eat,(5),(6)

-every day, you eat three servings of whole grains, salad, and another vegetable, along

  with a glass of wine

-snack on nuts

-every other day 1/2-cup of beans

-twice a weak poultry

-twice a weak 1/2-cup blueberries

-weekly once dine on fish

-oil should be olive oil

What exercises are needed?

There are not many studies on this subject, however, some exercises are better as it 

may protect the brain in the cases of higher risk for Alzheimer's disease

one study in 2014 in Frontiers in Aging Neuroscience, which recommends

-at least 2.5-hours moderate activity per week

-brisk walking

-muscle-strengthening activities

MIND Diet Examples

Breakfast

-yogurt, with raspberries with almonds

-wheat toast, scrambled eggs, almond butter

-oatmeal, strawberries, boiled eggs

-yogurt,banana,peanut butter

-wheat toast, omelet with peppers, onions, avocado

-oats overnight soaked with strawberries

-spinach frittata, apple, peanut butter

Lunch

-tuna salad,wheat bread,carrots,celery,hummus

-fish tacos, wheat bread, brown rice, pinto beans

-ground turkey

-baked trout, collard greens, black-eyed peas

-salad,black beans,grilled chicken,corn,onion

-sandwich, chicken, blackberries, carrots

-whole-wheat pita, salad, chicken

Dinner

-chicken, vegetables, brown rice

-salmon grilled, salad, brown rice

-brown rice, black beans, vegetables

-whole-wheat spaghetti,salad,meatballs

-oven-roasted potatoes, salad, wheat bread, chicken

-whole-wheat pita, salad, chicken

-brown rice chicken curry, lentils

So, from this blog, Nootropics facts, we do recommend following this MIND diet, for

persons who are aging, just to prevent the faster aging, it's very important, what very

silent key factors are we must adhere to get maximum benefits

-First point is not to use sugar at all, no surgery products

-Second point, is not to use butter, cheese, or margarine, or only use little

-Third point, no more fried products you can use grilled and roasted ones

-Forth point, no hard meat only chicken, fish, and egg

-Fifth point, no starchy vegetables only leafy

These are good points for any diet, so try to change food habits and try to adopt a very

healthy diet, which gives strength to the brain

Vinpocetine

What is Vinpocetine? 

It's a very powerful drug, also called ethyl apovincaminate, its lab-made derivative of

vincamine which is isolated from plant vinca, so you can say half natural and half synthetic

so let's go through this plant vinca from which vincamine is isolated, it is sold as its brand

name,Cavinton and Intelectol,(1),(2)

What is this vinca plant?

It's very common flowering plant, called by popular name periwinkle, and this vincamine is

extracted from seeds and leaves of this plant, and further in the lab this vincamine is converted

to this drugvinpocetine

lets see

                    nootropics facts, vinpocetine

Where this vinpocetine is used?

People use this for a variety of purposes such as

-improving memory

-improving thinking power

-boosting energy

-weight loss

but unfortunately, there is not much clear scientific evidence to support its uses, in fact, its a very controversial drug but in spite of all this it's used in supplements meant for nootropics, that

the real surprise, the medical community is highly divided whether it has any great usefulness

let's see what they think,(3).(4)

apart from its nootropics application, this drug is also promoted for the following health

 conditions again here also we don't have enough support from research data,(5),(6)

-age-related eye problem, AMD

-age-related hearing loss

-taking vinpocetine along with ginkgo improves memory

-reduces brain damage due to acute stroke

-for tinnitus,(ringing in the ears)

-for loss of bladder control,(urinary incontinence)

-Alzheimer disease

-Motion sickness

-Seizure disorder,(epilepsy)

-Menopause problems

It's status

It's used in Japan, Russia, and some European countries, but not in the US, Canada, Australia

, New Zealand but still sold as in supplements, where mostly it is used with ginkgo as a

 memory booster supplement

Where does it stand from the Nootropics Facts point of view?

Although it is used in many supplements meant for nootropics, but the problem is

that we don't have enough research data in the support of vinpocetine, at this situation

we feel very much reserved in recommending this drug for nootropics, after all, facts

should not be ignored

Nootropics and alpha-GPC

What is Alpha-GPC?

Its total exact name is L-alpha glycerylphosphorylcholine or another most used name

cholinealfoscerate,a natural choline compound, occurs in the brain, and its role is to transfer

choline across the blood-brain barrier

It also happens to be a biosynthetic precursor for acetylcholine, in lay-man terms it 

converts itself to acetylcholine,in the bioprocess which is constantly going on in

the body, more particularly in the brain.

Today its made in a lab and can be used as medicine,(1)

What is the role of Alpha-GPC?

As discussed its role is to manage, regulate choline in the brain, because of its this role

it becomes very important as nootropics, by taking it as a supplement, provides more

acetyl-choline, and intern more benefits to brain problems,(2)

,

Production of Alpha-GPC

Mostly it is made by a chemical or enzymatic process from soya phospholipids, which also

occurs in lecithin, mostly from eggs and soya

Sources of Alpha-GPC

Its look like its widespread in most of food products but only in very small amounts, 

the sources maximum rich are only just follow

Wheat bread.....................................     4,93 mg/100 gram

Oat barn.............                                   33.25mg/100 gram

Cream cheese...........                             9.26 mg/100 gram

Yogurt..........               ..............          8-to-9-mg/100 gram

Bananas.........    .............                       5,60 mg/100 gram

Mushrooms..............         .............       5.11 mg/100 gram

Cabbage...........     ........            ........    3.47 mg/100 gram

Salmon..........     .............                      5.89 mg/100 gram

Comparison with other choline analogs

What reported is that Alpha-GPC works much better in compression with

other choline analogs means it needs only 46% dose to create the same effect

what 100% dose of CDP-choline provides, so definitely it is more better

the choice for choline related treatments

Alpha-GPC affects on Obesity and Fat- and Weight-reduction

As we already discussed, not much research data is available, but whatever we have

indicates that it works, it creates LIPOLYSIS, which means creates ketones and free fatty

acids, once it is taken in, a similar condition which is created by keto-diet.

lets see

                                  nootropics and alpha-GPC

It can affect physical performance

It is reported to increase about 14% more out-put, if it is taken about 45- minutes before

exercise

It improves the conditions of Ischemia and Stroke cases

Very significant improvements are reported in these cases, it's very important neuroprotective

in both cases

What are the other health benefits of Alpha-GPC?

There is not much research inputs about its benefits, whatever very primary research data

available indicates that it can provide some good benefits in the following areas,(3),(4)

Alzheimer disease

It is reported to work in this case, improve the symptoms in a very considerable way

Dementia

It improves the conditions, behavior, mood, and thinking areas

Improve memory

Improve thinking  process

Improve learning

What are the side effects or negative effects of alpha-GPC?

Although it's very much tolerated, still some side effects are reported and most of

them are very mild in nature, they are heartburn, headache, dizziness, and in prolonged

use skin rashes

There is not much research information available so be on the very safe side and don't use

if you are pregnant or breast-feeding

What is the status and doses of this Alpha-GPC?

Most of the time it is available on the counter, which means you don't need prescription

about doses not much clear although its also depends on a lot of other conditions may be age

and health, follow the instructions provided by the supplier, mostly safe dose is 1000mg per day

in divided doses of 500mg.

Does Alpha-CPC is a very good nootropic?

Alpha-GPC is only working, in the area of the brain, as it is controlled and regulate the choline

it can be the safest choice for nootropics, and in fact, it is already used in a large scale for

this purpose only, and also the truth is it is used in a number of supplements meant for

nootropics.

Where does it stand from a nootropics-fact point of view?

When we see a lot of drugs for nootropics, this alpha-GPC just stands out as something very

special, at least it is safest and very active for brain functions, we think it can be and should

be considered as most important choice as nootropics

Nootropics and glutamic acid

Glutamic acid

Glutamic acid is an amino acid used by almost all living species, it contributes as an

 important part of biosynthesis for proteins, the human body makes it for its needs,

 it involves in the functions of the nervous system, the very interesting part is that

 it occurs in protein gluten which also happens to be the major protein of wheat,

 so it's plenty around us,(1)

It is manufactured by either hydrolysis of the protein gluten, or from wastewater

 of beetroots, or by fermentation

What is the connection of glutamic acid with the brain?

This is an amino acid that is involved between nerve cells and brain cells, which means

 it involved in sending and receiving information, so its very key amino acids involved

 with brain functions,(2)

let's see

                               nootropics and glutamic acid

Does MSG, monosodium glutamate has the same acid?

Yes, its the same acid, only here it is used as the sodium salt, MSG has a lot of controversy

and some people working with the health system regard this as a little unsafe, although

the FDA says it's very safe. Its food additive also called as number E621 used very widely

as a flavor enhancer in processed foods

MSG contributes in a very big way as a flavor enhancer mainly for savory, meaty, and

 umami foods, here umami is referred to as the fifth taste along the line of salty, sour,

 bitter, and sweet today daily intake of MSG in the US and UK is about 0.55-to-0.58

 gram per day, while the same in Japan and Korea is about 1.2-to-1.7 gram per day

Why MSG regarded by some people as a little unsafe?

There is not much research support for this, of course, very large doses of MGS can raise

glutamic acid levels in the blood, which means increased glutamate activity in the brain and 

can harm, but who eats that kind of high amounts

Glutamic acid health benifites

Although not much research has been done, whatever very little information we have it is

helpful in a number of health conditions

-may be helpful in treating childhood behavioral issues

-maybe helpful in personality development, mainly to Childs

-may be helpful for the treatment of epilepsy and muscular dystrophy

-maybe helpful in managing intellectual disorders

-may be helpful in the treatment of low blood sugar,(hypoglycemia) in diabetics

-maybe in preventing nerve damage in cases of chemotherapy

Glutamic acid side effects, toxicity, and possible interactions

In practice glutamic acid is not taken as a signal item most of the time it is used

in formulations along with either other amino acids or with vitamins, and again

in the formulations pinpointing side effects is a little difficult, but again what

research says,(3)

no high dose for a long lime

no for women, pregnant or breastfeeding

no for someone who has maple syrup urine disease, or MSUD, a kind of metabolic disorder

no for cystinuria, its a kidney disorder

Why glutamic acid is important as nootropics?

There is very little research information we have about its direct role as nootropics

but as it is a very important part of the glutamine cycle which really involved in high

levels of nootropics activity, it might be thought that this acid may also be useful

in nootropics activity.

let's see

                           nootropics and glutamic acid

Is glutamic acid is used as a nootropic in formulations?

Yes, and that is the reason we are trying to cover its all facts so that it should be more 

clear, whether it should be used or not, as for as commercial information is concerned

glutamic acid is a part of formulations that are marketed as supplements meant for

nootropics

So, what is a recommendation from Nootropics Facts, as already you see it does have

indirect relation with glutamine, but whether glutamic acid also works in a very good way

is not very clear, there is not much research support on this

How to buy nootropics? 

Most of the nootropics which are natural type and some drug type you can purchase from any pharmacy on the counter or you can buy from online suppliers. before buying the most important  is to make sure that you are buying the correct stuff for this,(1)

Let's see 

                                      How to buy Nootropics

Read the labels very thoroughly

Read the reviews  about products 

If possible  discuss with your doctor 

Use the product very strictly  according to  instructions 

You can also buy supplements,  they have formulated mixtures of more than one nootropic and some of them are very successful, you can again buy them from online suppliers, like Amazon

Nootropics and Choline

What is choline?

Very recently only in 1998, choline is recognized as an essential nutrient,  and this is made by the body for its own needs.it's required for the normal function of the body for normal health. Although the body makes but a large amount also comes from food that we take every day.It's an organic, water-soluble  compound its neither vitamin nor mineral  and often grouped along with the vitamin B complex group due to its similarities,

 it impacts on

Liver function 

Healthy brain  function 

Nerves system  function 

Metabolism  function 

Therefore adequate  amounts  are always  needed for the body to function  properly,(1),(2) 

Let's see

                                       Nootropics and choline

What choline does?

Choline plays a very important  role in many processes  going on in the body some of them are

Cell structure 

It makes the cell membrane 

Cell messaging 

It is involved in  the  production  of  compounds  that acts as cell messengers at transport and metabolism It's required  for removing the cholesterol  from the liver, if it is inadequate  then there is the buildup of cholesterol  levels 

DNA synthesis 

Choline with vitamin -B12, and Folic acid takes part and produce DNA

Nervous system  maintenance 

It's important to produce  acetylcholine which is a neurotransmitter for the nervous system 

And this is also involved  in 

Memory 

Muscle movement 

Heartbeat regulations 

Other basic functions 

How much is required? 

This also depends on  gender and age and health conditions but a healthy individual  needs about 550mg/ day

What are health benefits? 

1., May be helpful to  Heart health 

Choline may reduce the risk of heart  disease  by lowering the homocysteine levels 

2,:-May help in Brain problems 

It regulates and improves 

Memory, mood, and intelligence 

Better memory and processing

Brain development 

Mental health  disorders 

Mood disorders 

Bipolar disorder 

3,:-May help in liver disease 

It reduces  liver risk by 28%

4,:-May help in Cancer

There are mixed results  and more research is  needed

What are the negative impacts? 

Taking too much choline  can be harmful it can create  side effects  such as a drop in blood pressure, sweating, fishy body odor, diarrhea, nausea, and vomiting The upper limit is 3500mg/day, this limit is just not possible if you are not taking any choline supplements,(3),(4)

Does it good for nootropics? 

It has all properties to help Brain, and because of that it is good for nootropics and in fact is already present in many supplements meant for nootropics. 

So, where does choline stands, as for as nootropics facts are concerned choline is too important as a nootropic, about nootropics activity its basic molecule involve in brain activities, we think choline and choline derivatives can be a very interesting choice as nootropics?

Nootropics and Carnitine

What is Carnitine?

L-Carnitine is a derivative of naturally occurring amino acid, its very popular,  and used for bodybuilding, fitness, and weight loss programs as a supplement. In a broad sense, it is a nutrient and dietary supplement 

It's produced in labs and it is a synthetic product, the body itself produces it for its needs, very small amounts it can be managed from food, what we eat particularly meat and fish. For some people, vegans or people with certain  genetic  issues, it has to be given as a supplement,(1).,(2)

 Let's see 

                            Nootropics and  Carnitine

What are different types of carnitine?

The several types of carnitine which are used for supplements  are

L- Carnitine

This is the most required type and standard  bioactive form of carnitine

D-Carnitine

This is a very inactive form, it should not be used

Acetyl- Carnitine

Most active form for the brain, this is more beneficial for people with neurodegeneration.

Propionyl - L-Carnitine

More active form for blood circulation improves blood flow

L -Carnitine-L-Tartarate

More active form for supplements  meant for sports, weight loss For most people, acetyl-L-Carnitine is the best working type

How it works? 

Its main role in our body is

1,:-Energy production

2,:-Mitochondrial function

In cells carnitine transport fatty acids, where they burn and produce energy,  for this purpose, most carnitine, about 90% only contained in muscles where it produces energy by utilizing fatty acids as fuel, and in turn, it helps in weight loss.

Where it occurs in nature?

                            Carnitine  in Nature

What are the health benefits of  Carnitine? 

Carnitine is associated with energy production that too in muscles, where it utilizes fatty acids rather than carbohydrates.

1,:-May help in weight loss

It really works, research studies confirm this.

2,:-May help in exercise  performance 

These benefits  are indirect and it takes  time, these are long term benefits,(3) 

Recovery

May improve  exercise  recovery 

Muscle oxygen supply

May increase oxygen supply to muscles

Stamina 

May increase blood flow,  delay discomfort, and reduce fatigue 

Muscle Soreness

May reduce muscle  soreness after exercise 

Red blood cell  production 

May increase the production of red blood  cells, which are also responsible  for oxygen 

Transport to full body

3,:-May help brain

It provides  almost all-round  health benefits  in this area studies suggested that

It prevents age-related mental decline

It improves  markers of learning 

It protects the brain from cell damage 

4:-May help Heart

It reduces  blood pressure 

It increases blood  circulation 

5,:- May help in diabetes  type2

It reduces blood sugar levels 

It improves  your body ability  to use carbohydrates 

What are the negative impacts? 

There are no negative effects  seen  in people  taking it 3 gram/ day, some people  reported  some mild side effects  such as  nausea and  stomach discomfort 

What should be dosed?

Although  recommend doses varies from 500 to 2000 gram/day depending on for what the purpose it is  used

Who should take it?

Older adults,  vegans, and vegetarians

Some very specific  use such as for cases of brain, and blood circulation 

Does it good for nootropics? 

If you see it used for more betterment for the brain, so it should  be used as nootropics in fact, it is used in a lot of supplements  meant for nootropics 

So what we have to say about this, from nootropics facts point of view, it's most trusted drug today, about nootropics activity, it has more than enough activity in the area of brain and brain functions, its side effects are also very limited, all said and done it can be very good choice.

Nootropics and DMAE

What is  DMAE?

Actually, it is chemical, its name is dimethylethanolamine, it's bifunctional, which means it has two reactive groups, one anime other alcohol, its colorless, viscous liquid with little ammonia smellIt's totally  synthetic  means it is made in labs, not isolated from  any natural product 

DMAE bitartrate

It's bitartrate salt, is a white powder, and mostly it is used as a dietary supplement, it has37% DMAE in it DMAE is naturally  produced in the body, which means it is present in the body, it's also present in fatty fishes such as anchovies, sardines, and salmon.,(1),(2)

Let's see 

                               Nootropics and  DMAE

How it works? 

It works by increasing the production of acetylcholine, a neurotransmitter involved in sending signals to nerves. Acetylcholine is also supposed to be responsible  for regulating many functions of the brain such as,(3),(4)

Sleep

Muscle contractions

Pain responses

Also, prevent the formation of beta-amyloid buildup in the brain, beta-amyloid is responsible for the age-related decline of brain function,  such as memory  loss

What are the health benefits of DMAE? 

There are not many  research studies in this area, and also whatever  information  we have is an old one

1,:-Support memory 

Very little evidence  in this area, it may be helpful to  protect memory 

2,:-Reduce hyperactivity

In this area, it is reported to  be helpful,  particularly  in children's 

3,:-Improve moods

Research studies indicate that DMAE  helps in this area 

Reduces depression, anxiety, and irritability

Increases motivation and initiative 

Enhance  mood

4,:-Enhance athletic  performance 

It improves  athletic  performance  when given  with vitamins and other supplements but we need more  research  in this area

5,:-May help in the Skin area

It works in this area, and a small study  is there to support  this

It hydrates skin

It improves  skin appearance 

It reduces fine lines around the eyes  and on the forehead 

Reduces wrinkles  of skin

Improve the firmness of the skin

What are the negative impacts?

Should not be taken by those having epilepsy, schizophrenia, and bipolar  disorders

Don't take if you are or might pregnant

Don't take if you are breastfeeding

What is the potential risk?

If taken in high doses,  it can trigger 

Skin irritation, redness, and swelling 

Muscle twitching

Insomnia 

Sneezing, coughing, and wheezing

Eye irritation 

Convulsion, only to very rare cases

It can also trigger  potentially  dangerous  interactions to certain medication,  so must 

inform your doctor 

What are the other names of this product? 

Apart from calling it as DMAE, its also called as

Deanol

Acetamido-benzoate de deanol

Benzilate de deanol

Bisorcate de deanol

Cyclohehylpropionate deanol 

Deanol  aceglumate

Deanol hemisuccinate

Deanol  pidolate

Deanol  tartrate

Does it worth as nootropics? 

In spite of side reactions  and also not much information  available  about these products, this is also one of the most used products in supplements meant for nootropics.,(5) 

So where do we stand, from nootropics facts point of view, this product is great, its effective about nootropics activities also it works, and doctors are using it in a big way, and a lot of research studies information we have, we think it can be used as nootropics, but as it is the drug, you must inform your doctor before taking a decision about this.

Nootropics and Nicotine

About nicotine

It's tobaccos main ingredient, widely used as a stimulant, and at the same time highly addictive, and very well known for its bad effects,  so what is good about it. according to  research  carried out, where pure nicotine,  not tobacco, is tested and it found,(1),(2) ,that it can protect from

Alzheimer's disease 

Parkinson's disease 

Even ward off these diseases 

Even it reduces  the  anxiety 

Improve memory and concentration 

But because its bad effects are so high, the medical circle does not want to take the risk.

Let's see 

                                 Nootropics and Nicotine

Does it act as nootropics? 

It does have some good effects on the brain, but whether we should use it as nootropics is a question,  unanswered,  however, it is used in some supplements meant for nootropics,(3). 

So, what we have to say about this, from a nootropics facts point of view, and about nootropic activities it provides a very great picture, but again possibilities of bad happening, and addiction stop us to say that it can be a too good a choice, although it is used in supplements meant for nootropics

Nootropics and Caffeine

About Caffeine 

This is a natural ingredient of tea, coffee, and cacao plants, and also maybe the most used ingredient in the world,  most of the people start their day,  from this.It works on the brain and CNS system and provides energy,  stimulation, and alertness. Its history  is as old as 2737 BC, with the discovery of  tea now, today its also main ingredient of  caffeinated soft drinks and also in almost all energy drinks,(1).,(2)

Let's see 

                        Nootropics and  Caffeine

How it works? 

Most of the caffeine is taken orally,  and is absorbed, and goes to the main bloodstream very fast, from there it reaches the liver where it breaks down to smaller compounds which further, go to almost all parts of the body's main function is in the brain, where it blocks the effect of adenosine. Adenosine acts as a neurotransmitter and what it does is, make the brain  slow down, or relax, in the end, this translate to  tiredness, so caffeine  overcome the effects  of tiredness, make fresh good mood and feel fresh In the process of overcoming the adenosine effect, caffeine  goes the other way and keeps you alert, stay awake, also increases the levels of adrenaline which  increases brain activity by more release of,(3),(4)

Dopamine

Norepinephrine

These both are very important neurotransmitters, keep the brain very active.

How fast caffeine works?

Caffeine  works very fast, the moment you drink coffee,  it takes only less than  20 minutes for caffeine  to reach the bloodstream, and almost about one hour to create the full effect 

What are the health benefits of  Caffeine?

1,:-Improve the brain function 

It affects the brain in a big way and that too in speed

Good mood, or mood elevation

Improved alertness

Improve reaction time

Help in Alzheimer's disease 

Help in Parkinson's disease 

2,:-Increase metabolism 

As it stimulates CNS, it increases metabolism by 11% and this results in fat burning which also get the increases by 13%, in nutshell, it means that if you take 300 mg of caffeine it can burn about  79 calories. 

3,:-May enhance exercise performance 

It delays muscles reaching exhaustion

It improves  muscle contractions

It increases tolerance to fatigue 

It reduces  perceived exertion

It helps in team sports,

It helps in high intense workout 

It helps in resistance  exercise 

4,:-May be helpful  in Heart health 

Caffeine does not raise heart risk, actually it is the other way around it lowers heart risk about 16 to 18% for men and women who are drinking  1 to 4 cup of coffee per day, more precisely about 100 to 400 mg caffeine per day. It can raise blood pressure in a very small margin about 3 to 4 mm, hg only, and also attend to fade after some time.

5,:-May help in diabetes 

It lowers about 29% risk of developing diabetes type-2

6,:-May protect the liver

It reduces  the risk  of liver damage  by as much as 84%It may slow disease progress It improves treatment  response It lowers the risk of death  because of  liver problems 

7,:-May help in Cancer

Drinking  2 to 3 cup of coffee  may reduce cancer risk

Liver cancer by 64%

Colorectal cancer by 38%

Skin cancer by 20%

8,:- May help gut health 

It may increase activities  of gut-friendly  bacterias,  and it kills bad bacterias 

9,:- May help in Gout

It may reduce the risk of  developing  gout 

In men about 40%

In women  about  57%

10,:- Reduces multiple sclerosis, (a chronic illness  involving  CNS )

It reduces  the  symptoms, in this disease, also reduces  the risk of developing  this disease  by 30%

11,:-Longevity

Drinking  coffee  may decrease  the risk of death by 30% in cases of diabetes 

What is the negative impact? 

Most importantly it is habit-forming some side effects are anxiety, tremors, restlessness, irregular heartbeat, trouble sleeping. It can increase headache and  migraine and high blood pressure  in some individuals It can also increase the risk of  miscarriage There is the possibility  that it can react with  medication  if you are taking  and avoid caffeine  if you are taking 

Zanaflex, a muscle relaxant

Luvox, a antidepressant

What is recommended dosages of caffeine? 

From USDA and EFSA, the recommendations are only up to 400mg/ day, in terms of coffee it is 4 cups of coffee.

Does caffeine fit as good nootropics? 

Well, most of its activities are in the area of the brain, it's very affordable and manageable, and already it is used in many supplements meant for nootropics. 

So as for as caffeine is concerned, from a nootropics facts point of view it's just great it works that too works very fast, about nootropics no one should have any doubt as most of the people any way using it in the form of tea or coffee, it can be a very interesting choice, the only thing it may be addicting

Nootropics and Bacopa

What is Bacopa?

It's called Bacopa monnieri, water hyssop, Indian pennywort, herb of grace, Brahmi it's a very common herb that grows on a wetland in North and South America, Africa, Asia, Europe, India, and Australia.  For centuries  this herb is used in Ayurveda only for one purpose,  increasing  memory,  It has a very powerful  rare molecule,  called  Bacosides and most of the health  benefits are due to this molecule,(1),(2)

Let's see 

                                     Nootropics and  Bacopa

What are the health benefits of  Bacopa?

1,:-It acts as a very powerful  antioxidant and helps the brain

Bacosides and some other compounds  present  in Bacopa acts as a very powerful  antioxidant, it reacts with free radicals responsible  for lipid peroxidation, these oxidized lipid molecules, in the end, lead to a neurodegenerative process which gives birth of

Alzheimer's disease 

Parkinson's disease 

Now here the molecules  present in Bacopa interact and prevents this lipid peroxidation, here it proves that Bacopa helps in brain problems Research studies also show that it helps in dementia and reverse the signs of

memory impairment 

2,:- It has very powerful  anti-inflammatory  activities 

It suppresses the release of pro-inflammatory cytokinins, a type of immune response which creates inflammation. It also inhibits enzymes,  cyclooxygenase, caspases, and lipooxygenases these enzymes are responsible for  generating  pain and inflammation  in the body, so Bacopa inhibit them, and by doing so  it helps in pain and inflammation In one animal study, Bacopa is compared with diclofenac and indomethacin, the two most used drugs for inflammation  and pain although  more research is  needed whatever  animal studies  we have, showBacopa is a powerful  anti-inflammatory 

3,:- May boost most of the brain functions

In Ayurveda, an alternative treatment method of India, this Bacopa, which is called Brahmi is used for memory enhancement what modern science says, the research studies indicate that increases dendritic lengths and branching, which means that dendrites, a part of nerve cells in the brain closely linked with memory and learning. by strengthening  these dendrites Bacopa supports 

Memory  and learning 

Significantly  improve the speed of processing  visual information 

Improve  memory, attention, and ability  to process information 

4,:- May help in ADHD

ADHD, (attention  deficit  hyperactivity disorder), a neuro disorder,  which is characterized by  symptoms  such as

Hyperactivity 

Impulsivity

Inattentive news

Restlessness

Poor self-control 

Bacopa is reported to  help in this case, and significantly  reduce  these symptoms 

5,:- May provide  help in stress, anxiety, and depression 

Research studies indicate that  Bacopa is very powerful  in this area

It elevates mood

Reduce the levels of cortisol, a hormone responsible  for  stress and anxiety Its anti-anxiety  benefits  are very close to lorazepam,  a drug used for the treatment  of

Anxiety 

It reduces  significantly  depression Of course, more research  is needed  in this area, but whatever primary  research information  we have only shown that Bacopa  is very friendly  with  brain

6,:-It can be helpful  for  heart

It lowers blood pressure  both, systolic and diastolic, this it performs by generating nitric oxide, which dilates blood vessels, increases blood flow

7,:-May help in Cancer

It has molecules, which have anti-cancer properties,  research  studies  shows can kill, aggressive  brain cancer cells can also be effective  in  skin and breast  cancer but again these reports are  from animals,  rats there are no reports  from humans more research  is needed  in this area

What is the negative impact? 

It's very safe for most people,  but some people  develop  some side effects  such as nausea, stomach  cramps, and diarrhea We don't have much information  about its safety, it can interact  with the medication if you are on any, so better inform your doctor before taking it.,(3),(4),(5)

Does it a good nootropic? 

Well most of its activities  are  only for the brain, which makes it almost the first  choice  for nootropics 

How to take it?

It's available in powder, tablets, capsule form doses are 300 to 450 mg, Bacopa extract per day powder can be used in the form of tea Some people mix the powder in butter, or ghee,(a form of clarified butter), and use it along with hot water or milk. 

So where do we stand, from nootropics facts point of view, about nootropics activity no one can have doubt, as this bacopa, another name, Brahmi, is very old, time tested., and used by Ayurveda, Indian health system only for memory, now we know its good for a lot of other brain functions, we feel it can be trusted, should be tried as number one nootropics.

Nootropics and Lions mushroom

What are Lion's mushrooms? 

It's also called, lions mane mushroom, monkey head, beard tooth, satyrs beard, bearded hedgehog, pom pom, the mushroom also called bearded tooth fungus is an edible  mushroom that belongs to the tooth fungus  group,  it grows in North America, Europe, and Asia and they grow on hardwoods, particularly  on American  beechwood mostly on dead trees

It can identify because  of  its long spikes ( greater than 1 cm length ) in spite of its great popularity  that it can provide  great health benefits,  modern science does not provide  very clean and clear support for  these health claims They have flavor as see-food like, often it can be compared with crab or lobster .these mushrooms  are used in culinary and also in medicines in countries  such as China, Japan, and Korea The extracts are used in medicines,(1),(2),(3)

Let's see

                            Nootropics and  Lions mushroom

What are the health benefits of lion mushrooms? 

They are very rich in very  rare bioactive molecules,  and whatever little research information we have, it indicates  that they have unique  type of  health benefits 

1,:-May be helpful in Dementia

Lion's mushrooms have two ingredients that are found  to  be active against brain aging, they  can stimulate  brain cells these are

Hericenones

Erinacines

Research studies have indicated that lions' mushrooms can protect in Alzheimer's disease,  a degenerative brain disease, which causes memory loss. however, more research is needed in this area.

2,:-Helps in Depression, Anxiety  

It works and reduces some symptoms of anxiety  and depression 

3,:-May help in the recovery of nervous system  injuries 

It stimulates the growth and repair  of nerve cells in any part of the body whether it is in the brain or in the spinal cord 

4,:-May help in ulcers in the digestive system 

Stomach  ulcers are caused by mostly two reasons 

1,:-By overgrowth of a bacteria  H.Pylori, which damages stomach  layers

2,:-By long term use of the nonsteroidal anti-inflammatory  drug (NSAIDs)

Lion's mushroom  extract found to work in this case, it reduces inflammation and also prevents damage  of tissues  in other areas of the intestine 

3,:-Help with Heart problems 

It lowers triglycerides levels 

Also, prevent oxidation of  cholesterol,  oxidized cholesterol  molecules tends to attaching the walls of arteries and this hardens them, it increases the risk of heart stroke lions mushroom  is helpful  as it prevents this oxidation also another ingredient  in lions mushroom  called, Hericenone B, which decrease the rate of blood clotting and by doing so it protects the heart

4,:-Help in diabetes 

It may be helpful  for diabetes  management,  improving blood sugar  control,  reducing complications  arising from diabetes 

reduces nerve pain in hand and feet

It blocks an enzyme  alpha-glucosidase, and by doing so it increases the breakdown  of carbohydrates  in the small intestine 

5,:-May help in Cancers

It has unique  compounds  which have anti-cancer properties, they kill cancer cells and it is found  to be more effective  in particularly  colon, stomach, and blood cancers

6,:-Reduces Inflammation 

It has a lot of ingredients, which act as antioxidants, and because of that, it developed anti-inflammation properties. also reduces oxidative stress

7,:- Boost immune system 

It also boosts immunity,  by increasing the activities in the gut, making it more efficient so that it can fight bad bacterias. 

What is the negative impact? 

There is very little information  on this account,  they appear  to be very safe but some people reported to have allergies,..so at least  those person's must avoid those who have a history of mushroom  allergies,(4)(5)

Does it good for Nootropics?

It's already present in some supplements which are meant for use in Nootropics. 

So, where do we stand from nootropics facts point of view, about nootropics function it works, it's very effective, and already its time tested, as it is used for centuries, so it can also be the first choice if you are looking for a good working nootropics

Nootropics and Rhodiola

What is Rhodiola?

It's also called Rhodiola roses, a flowering plant that grows in Europe, Asia, North America its roots are considered  as an adaptogen, meaning, helpful in stress its root contains more than 140 active ingredients, of which two molecules  are very unique,  these are

Rosavin

Salidroside

In Russia and other Scandinavian countries, the Rhodiola is used for centuries for the treatment of,  stress, anxiety, fatigue, and depression.  Today it is very widely used in number of health supplements,(1),(2),(3)

Let's see 

                                     Nootropics and  Rhodiola 

What are the health benefits of Rhodiola?

It's very rich in a lot number of bioactive molecules, and also long been known as adaptogen means a natural substance that helps the body to fight stress.

1,:- Reduces stress, anxiety, and depression 

It works, it provides  health benefits in this area

2,:- It can reduce fatigue 

Fatigue  is the major  cause for the feeling of mental and physical  tiredness, and fatigue comes from stress, anxiety, and sleep disorders, Rhodiola due to its adaptogenic properties provide help and reduce fatigue,  and its symptoms  it also increases

Mood

Concentration 

Attention 

Emotion

3,:- It can manage  depression  in a better way

Depression is a very common problem, but we can not call it a serious illness, and if it continues it leads to negative performance and actions.it occurs by unbalanced neurotransmitters in the brain, and in this situation doctors give drugs, they are also called anti-depression drugs. but Rhodiola does this job and does it better way, and by a lot of people, it is used for this purpose only.

4,:-It improve brain function 

Exercise, proper nutrition, and good sleep this is what is needed for the brain, and here 

Rhodiola  works very well it

It reduces mental fatigue 

Improve performance 

Improve  sleep quality 

5,:-Can improve  exercise  performance 

Everyone wants better results from exercise whatever he does, but all the time results may end up in frustration only, here Rhodiola can help.it has the potential  to decrease perceived exertion, and by doing so it can allow you to exercise  more harder way for achieving your goals,(4),(5)

6,:-Can help in diabetes 

It lowers blood sugar, and thus provides help in diabetes 

7,:-It has anti-cancer properties 

It has some ingredients  which have very potent anti-cancer activities,  it inhibits the growth of cancer cells in more particularly  breast,  colon, liver, bladder cancers

How best we can take Rhodiola? 

Rhodiola  is available  in extract form in tablet and capsule,  it also available  as a tea, The most popular  is pill because in the pill you can plan your daily doses 

How to make sure that it is good stuff? 

Must check-in  labels,  it should have 

Rosavins 3%

Salidrosides 1%

What can be doses?

For stress, anxiety, fatigue, depression.   It can be 400 -to- 600 mg/day/single dose for performance-enhancing, it can be 200 -to- 300 mg/ day / single dose, an hour or two before exercise.

 When to take?

Don't take it before  going to bed, in the nighttime, as it has some stimulating  effect it can disturb sleep patterns also better take an empty  stomach 

Does Rhodiola have any negative impact? 

It's very safe and very well tolerated by most of the  people,(6),

Does Rhodiola is good for Nootropics? 

Rhodiola  is most used natural in supplements  meant for Nootropics 

So where do we stand, from a nootropics facts point of view Rhodiola is just great works very effectively about nootropics function it also works great and it covers most of the brain functions, from all practical purpose as nootropics, this can be regarded as the first choice.

Nootropics and Gymnema

What is Gymnema?

Its Gymnema, also called Gymnema tea, Gymnema Sylvestre, is a plant that grows in almost most parts of the world, Asia, China, the Arab peninsula, Africa, and Australia.  It's used in Ayurvedic medicines, for centuries and called Gurmar, very literally it means sugar destroyer. Its leaves extract is used in medicine,  it has a very unique  molecule  called Gymnemic acid it reacts with taste receptors on the tongue and thus suppresses the taste of sweetness apart from the above, it has

Gymnemic acid

Saponins

Flavonoids

Gurmarin

These are all very bioactive molecules, and they provide very vast health benefits,(1),(2)

Let's see 

                                          Nootropics  and Gymnema

What are the health benefits of  Gymnema Sylvestre?

1,:-Reduces Sugar Craving 

This is a very rare bio property, it blocks receptors for sugar, it reduces appetite for sweet food.

2,:-Lowers blood sugar levels 

It's true, it works, it has anti-diabetic properties,  it blocks the receptors in the intestine and thus blocks sugar absorption,  so lowers blood sugar in diabetes. 

3,:-May contribute  to an increase  in insulin  production 

This is another very good activity,  where it stimulates more insulin production

4,:-Help in Heart health 

It lowers bad LDL cholesterol  and triglycerides

It increases good cholesterol  HDL labels 

So it overall helps in most heart problems 

5,:-May help in weight loss

It helps in reducing body fat, body weight, also reduces  food intake, by suppressing appetite

6,:-May help in inflammation. 

It has polyphenols and saponin they create a power full anti-inflammatory  properties 

What are the negative impacts? 

It's very safe, but then we don't have enough research information about its safety, its better to inform your doctor, if you are on some kind of medication,  before taking it.,(3),(4)

Does it very good Nootropics? 

It's already used in supplements meant for nootropics. 

Whatever you may say, it is a very special, nootropics facts point of view you can not ignore this nootropic, this is just great, it works and works, about nootropics function also it has very unique performance, we think it should be the first choice for nootropics, and this is also true, its presence in the number of supplements meant for nootropics

Nootropics and Green tea

What is green tea?

It comes from the same plant, which gives very popular  tea, only for green tea some very special  processing  is carried out, it comes at least three types

Green tea in teabags

Green tea in powder form

Matcha tea

For nootropics  most powerful  is matcha, then green tea powder, and in the last green tea bags

What is so important in green tea?

Green tea has ingredients,  which normally  do not occur in another plant source, these belong to the polyphenol family and act as a very powerful antioxidant, most of the health benefits are mostly from these polyphenols,(1),(2),(3)

Let's see 

                                     Nootropics and  green tea

What are the health benefits of green tea?

1,:-May improve  brain function 

Caffeine  and L- theanine  both work together  and provide very good  benefits  for brain caffeine blocks adenosine, which also acts as an inhibitory neurotransmitter, and by doing this increases the neurons, dopamine, and norepinephrine, and in the end, it leads to improve  most of the brain functions

Mood

Vigilance

Reaction time

Memory 

L- theanine  is amino acid it can cross the blood-brain barrier, increase the activities which has an anti-anxiety  effect, it also increases  dopamine and alpha waves in the brain, a combination  of  caffeine and  L- theanine  produces some kind of  synergistic effect on brain

2,:-May protect the brain from aging?

Green tea affects the brain in the long term basis, it protects the brain from aging

It protects and helps in Alzheimer's  disease 

It protects and helps in Parkinson's  disease 

Lower the risk of dementia 

Because of all these effects, it is used in nootropics 

3,:-May help in diabetes  type-2

It improves the  insulin  sensitivity 

It reduces the  blood sugar levels 

4,:-May help in Heart health? 

It reduces bad, LDL cholesterol, and thus helps to  heart health 

5,:-May help in weight loss

 Reduces  the  fat in the body, burns fat to energy

 Reduces the total weight

Reduces waist circumference

 Reduced belly fat

6,:-May help in Cancer

Research studies  indicated  that green tea extract  works as an anti-cancer agent it lowers the risk of cancers  particularly,  breast, prostate, colorectal cancers

7,:-Very high in Antioxidants 

It has a very unique type of antioxidants,  which helps in most health conditions that involve inflammation.

 8,:- It reduces bad breath 

It suppresses the growth of those bacterias  which are responsible  for bad breath 

How to use it in a better way?

It can be used in the form of tea, you can add sugar,  honey, lime, milk, depending  on your liking.,(4)

Does green tea is better for Nootropics? 

Well it has large activities focused on brain health, mostly for protection against aging that's makes it very good nootropics, it already used in supplements meant for nootropics. 

What can be a negative impact? 

Most of the negative impact is because of caffeine,  if you take more, then caffeine toxicity comes as an issue. 

So all said and done from nootropics facts, it is very true that green tea is very unique and special, it has the highest antioxidant activities, much much height than a lot of other naturals so it has a special place, about nootropics activities also it's excellent, we feel it deserves first place in nootropics.